In your last book, you discussed the negative effects of using HA in creams. You claimed that it can dehydrate skin in low-humidity environments. What did you base this conclusion on? Are there studies that you can refer us to that support this? I have attached some information that I was given on this issue from another specialist. l

"The glycosaminoglycan hyaluronic acid (HA), or hyaluronan, is a major component of the extracellular matrix of skin, joints, eye and many other tissues and organs. In spite of its simple structure, HA demonstrates remarkable rheological, viscoelastic and hygroscopic properties which are relevant for dermal tissue function. Biological activities in skin, however, are also due to its interaction with various binding proteins (hyaladherins). Due to an influence on signaling pathways, HA is involved in the wound-healing process and scarless fetal healing.

In clinical trials, topical application of HA improved wound healing; in particular, acute radioepithelitis, venous leg ulcers, poor circulation and diabetic foot lesions responded to HA treatment. Moreover, as a topical drug delivery system, an HA gel has recently been approved for the treatment of actinic keratoses (. dry, scaly, rough-textured patches or lesions that form on the outermost layer of the skin after years of exposure to ultraviolet light, such as sunlight).

Therefore, ongoing research offers new horizons for the therapeutic use of this glycosaminoglycan which has been regarded as an inert structural component until recently."

I hope you will be able to respond to this question. Thank you.