I personally wouldn't use an SPF at night, but would find an alternative soothing cream or lotion without it. I don't know that it would do much harm, but if you have a tendency toward sensitivity, having an SPF ingredient on your face all day and all night might be an issue. Plus, a separate product designed for nighttime might be more hydrating.
What about the Eucerin Redness Relief Soothing Night Creme? Many people seem to like it. I had a sample of it and it seemed really nice when I used it.
Marcy